Researcher Information
Sharoni Michal
sharonim@mit.edu (123) 456-7890
The information provided below is for MIT researchers' use and is subject to change by EHS. For our legal disclaimer please see - http://ehs.mit.edu/site/content/legal-disclaimer
Agent Characteristics
Influenza A Virus
H1, H3, H4, H5, H7, H9
RG 2
Virus
Yes     Yes      
Family: Orthomyxoviridae. Enveloped, negative-sense single-stranded fragmented RNA viruses. 
HumansBirdsOther mammalsSwine
Aerosol / InhalationCut/ Needlestick / Non-intact skinMucous Membranes
Infectious dose: Unknown Incubation time: 1-7 days; mean of 2 days.
Health Hazards
Sudden onset of fever, chills, headache, malaise, body aches, and dry cough.  Later, may have sore throat, congestion, and runny nose.  Less commonly, pink-eye, nausea, vomiting, abdominal pain, and diarrhea.   H5N1: can cause more severe disease.
Available for H5N1.  Other vaccines (e.g. H7, H9) are in clinical trials. 
Oseltamivir, zanamivir, amantadine, rimantadine
Antivirals (e.g. oseltamivir, zanamivir, etc.) should ideally be started within 48 hours or less of symptom onset.  
Containment
BSL 2
ABSL2
Viability
10% household bleach (~0.5% sodium hypochlorite)70% ethanolActivated hydrogen peroxide (PREempt, Rescue)Quaternary ammonia (Quatricide, sklar, Lysol spray, etc.)Phenolic (Vesphene II)hydrogen peroxide and peracetic acid (Peridox)Fresh 2% glutaraldehyde (Gluterate / CIDEX)
Autoclave at 121°C for 30 minutes, or dry heat at 170°C for 1 hour
24 to 48 hours on hard, nonporous surfaces and for approximately 8 to 12 hours on cloth, paper and tissues.
Inhalation from aerosols generated when handling infectious material and direct contact of mucous membranes with contaminated gloves.
PPE/Containment
Wear gloves, lab coat, and appropriate lab attire (pants/long dress, closed toed shoes); eye protection, e.g. safety glasses, safety goggles recommended for liquids. Additional PPE may be required depending on lab specific SOPs for handling Influenza A Virus.
Work in a Biosafety cabinet is mandatory, Minimize use of sharps, use centrifuge lids or safety cups.
Spill Procedures
Notify others working in the lab.  Allow aerosols to settle. Don appropriate PPE.  Cover area of the spill with paper towels and apply an EPA approved disinfectant, working from the perimeter towards the center.  Allow 10 minutes of contact time. Cleanup spill materials and dispose as biowaste. Surface disinfect 5-10 minutes. Remove PPE and wash hands.
For large volume spills or biological spills in a public area, contact MIT's Biosafety Program or the EHS office (617-452-3477) during normal business hours.  If the spill occurs after hours or on weekends, activate the EHS ON CALL system by dialing Operations 3-4948 (617-253-4948) or MIT Police by dialing 100 from a campus phone or 617-253-1212 from a mobile phone.
Exposure Procedures
Flush eyes, mouth, or nose for 15 minutes at eyewash station.
Wash area with soap and water and rinse/scrub for 5-10 minutes.
Immediately report incident to supervisor, PI, or EHS Representative. PI/supervisor must submit incident report in Atlas within 24 hours.
Medical Follow-up
9:00am-4:00pm, weekdays:
contact MIT Occupational Health:
Phone: 617-253-8552
Address: 25 Carleton Street, Building E23, Cambridge, MA 02142
website		 8:00am-8:00pm, weekdays
10:00am-4:00pm, weekends
MIT Health Urgent Care
phone: 617-253-1311
address: 25 Carleton Street, Building E23, Cambridge, MA 02142
Or call MIT Police 617-253-1212		 Emergencies:
Call 100 from a campus phone or
617-253-1212 from a mobile phone
Additional comments
References
Created on April  5, 2021 at 12:12 PM (EDT). Last updated by Sharoni, Michal on Nov. 19, 2025 at 10:26 AM (EST). Owned by Zhong, Lu.
Lu Zhong
Michal Sharoni
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