Researcher Information
Sharoni Michal
sharonim@mit.edu (123) 456-7890
The information provided below is for MIT researchers' use and is subject to change by EHS. For our legal disclaimer please see - http://ehs.mit.edu/site/content/legal-disclaimer
Agent Characteristics
Epstein-Barr Virus (EBV)
RG 2
Virus
Yes          
Family: Herpesviridae.  Double-stranded DNA genome, enclosed within an icosahedral capsid, surrounded by a phospholipid rich envelope.  EBV infections affect more than 90% of individuals during the first two decades of life worldwide. Considered a human carcinogen by the World health organization (WHO) and (the American Chemical Society) ACS.
Humans
Cut/ Needlestick / Non-intact skinIngestionMucous MembranesSexual transmission
Infectious dose: Unknown. Incubation tim: 30-50 days
Health Hazards
Varied severity, from asymptomatic to fatal.  Infectious mononucleosis is the most common manifestation of EBV infection.  Fever, sore throat, dark spots on palate and throat, whitish exudate on tonsils, enlarged lymph nodes, and enlarged spleen (may feel tender in the left upper abdomen).  It can lead to rupture of the spleen.  Has also been linked to many other diseases and disorders, including certain kinds of lymphoma.
None available
None available
For Infectious Mononucleosis: supportive treatment. Corticosteroids may be considered in some cases. Do not give antibiotics, as a non-allergic measles-like rash can result. Avoid contact sports for 4-6 weeks.
Containment
BSL 2
ABSL2
Viability
10% household bleach (~0.5% sodium hypochlorite)70% ethanolActivated hydrogen peroxide (PREempt, Rescue)Quaternary ammonia (Quatricide, sklar, Lysol spray, etc.)Phenolic (Vesphene II)hydrogen peroxide and peracetic acid (Peridox)Fresh 2% glutaraldehyde (Gluterate / CIDEX)
Autoclave at 121°C for 30 minutes
Unknown
Ingestion, accidental injection, direct exposure to the eyes, nose, or mouth, or inhalation of aerosolized materials
PPE/Containment
Wear gloves, lab coat, and appropriate lab attire (pants/long dress, closed toed shoes); eye protection, e.g. safety glasses, safety goggles recommended for liquids. Additional PPE may be required depending on lab specific SOPs for handling Epstein-Barr Virus (EBV).
Biosafety cabinet recommended for procedures that can generate aerosols or splashes, Minimize use of sharps
Spill Procedures
Notify others working in the lab.  Allow aerosols to settle. Don appropriate PPE.  Cover area of the spill with paper towels and apply an EPA approved disinfectant, working from the perimeter towards the center.  Allow 10 minutes of contact time. Cleanup spill materials and dispose as biowaste. Surface disinfect 5-10 minutes. Remove PPE and wash hands.
For large volume spills or biological spills in a public area, contact MIT's Biosafety Program or the EHS office (617-452-3477) during normal business hours.  If the spill occurs after hours or on weekends, activate the EHS ON CALL system by dialing Operations 3-4948 (617-253-4948) or MIT Police by dialing 100 from a campus phone or 617-253-1212 from a mobile phone.
Exposure Procedures
Flush eyes, mouth, or nose for 15 minutes at eyewash station.
Wash area with soap and water and rinse/scrub for 5-10 minutes.
Immediately report incident to supervisor, PI, or EHS Representative. PI/supervisor must submit incident report in Atlas within 24 hours.
Medical Follow-up
9:00am-4:00pm, weekdays:
contact MIT Occupational Health:
Phone: 617-253-8552
Address: 25 Carleton Street, Building E23, Cambridge, MA 02142
website		 8:00am-8:00pm, weekdays
10:00am-4:00pm, weekends
MIT Health Urgent Care
phone: 617-253-1311
address: 25 Carleton Street, Building E23, Cambridge, MA 02142
Or call MIT Police 617-253-1212		 Emergencies:
Call 100 from a campus phone or
617-253-1212 from a mobile phone
Additional comments
References
Created on April  5, 2021 at 11:59 AM (EDT). Last updated by Zhong, Lu on Nov. 19, 2025 at  5:26 PM (EST). Owned by Zhong, Lu.
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