Researcher Information
Cheng Glen
glenccheng@gmail.com (123) 456-7891
The information provided below is for MIT researchers' use and is subject to change by EHS. For our legal disclaimer please see - http://ehs.mit.edu/site/content/legal-disclaimer
Agent Characteristics
Clostridium botulinum
SELECT AGENT
RG 2
Bacteria
Yes       Yes    
A gram-positive , spore-forming bacillus
HumansAnimals
Cut/ Needlestick / Non-intact skinIngestionMucous Membranes
Health Hazards
Botulism neurotoxin causes flaccid paralysis and may lead to fatal respiratory failure.  Symptom onset in food-borne botulism occurs within 24 hours after exposure, whereas wound botulism symptoms may take up to 2 weeks to manifest. 
None available
None available
Within 1 hour of ingestion of suspected food, gastric lavage or enema should be administered together with a cathartic (sorbitol). IV administration of botulinum antitoxin should be considered. Respirations should be monitored and assisted ventilation given if required.
Containment
BSL 2
ABSL2
Viability
10% household bleach (~0.5% sodium hypochlorite)Spores may be resistant to disinfectants
Autoclave at 121°C for 30 minutes
Survives well in soil, water and agricultural products
PPE/Containment
Wear gloves, lab coat, and appropriate lab attire (pants/long dress, closed toed shoes); eye protection, e.g. safety glasses, safety goggles recommended for liquids. Additional PPE may be required depending on lab specific SOPs for handling Clostridium botulinum.
Biosafety cabinet recommended for procedures that can generate aerosols or splashes, Minimize use of sharps
Spill Procedures
Notify others working in the lab.  Allow aerosols to settle. Don appropriate PPE.  Cover area of the spill with paper towels and apply an EPA approved disinfectant, working from the perimeter towards the center.  Allow 10 minutes of contact time. Cleanup spill materials and dispose as biowaste. Surface disinfect 5-10 minutes. Remove PPE and wash hands.
For large volume spills or biological spills in a public area, contact MIT's Biosafety Program or the EHS office (617-452-3477) during normal business hours.  If the spill occurs after hours or on weekends, activate the EHS ON CALL system by dialing Operations 3-4948 (617-253-4948) or MIT Police by dialing 100 from a campus phone or 617-253-1212 from a mobile phone.
Exposure Procedures
Flush eyes, mouth, or nose for 15 minutes at eyewash station.
Wash area with soap and water and rinse/scrub for 5-10 minutes.
Immediately report incident to supervisor, PI, or EHS Representative. PI/supervisor must submit incident report in Atlas within 24 hours.
Medical Follow-up
9:00am-4:00pm, weekdays:
contact MIT Occupational Health:
Phone: 617-253-8552
Address: 25 Carleton Street, Building E23, Cambridge, MA 02142
website		 8:00am-8:00pm, weekdays
10:00am-4:00pm, weekends
MIT Health Urgent Care
phone: 617-253-1311
address: 25 Carleton Street, Building E23, Cambridge, MA 02142
Or call MIT Police 617-253-1212		 Emergencies:
Call 100 from a campus phone or
617-253-1212 from a mobile phone
Additional comments
All Category A Infectious agents solid waste, e.g petri dishes, tubes, contaminated gloves, must be inactivated with an appropriate disinfectant before disposing into the biowaste box
References
1. https://www.canada.ca/en/public-health/services/laboratory-biosafety-biosecurity/pathogen-safety-data-sheets-risk-assessment/clostridium-botulinum.html
2. McLauchlin, J., Grant, K. A., & Little, C. L. (2006). Food-borne botulism in the United Kingdom. Journal of Public Health (Oxford, England), 28 (4), 337-342. doi:10.1093/pubmed/fdl053
3. https://www.uptodate.com/contents/botulism
Created on March 17, 2021 at 10:31 AM (EDT). Last updated by Sharoni, Michal on April  4, 2022 at 11:27 AM (EDT). Owned by Zhong, Lu.
Lu Zhong
Michal Sharoni
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